[HTML][HTML] Circadian clock molecules CLOCK and CRYs modulate fibrinolytic activity by regulating the PAI‐1 gene expression

N Ohkura, K Oishi, N Fukushima, M Kasamatsu… - Journal of Thrombosis …, 2006 - Elsevier
Disruptions of circadian rhythms are associated with the development of many disorders.
However, whether a disruption of the circadian clock can cause anomalies of the hemostatic
balance remains unknown. The present study examines coagulation and fibrinolytic
activities in circadian clock mutants, a homozygous Clock mutant and Cry1/Cry2 double
knockout (Cry1/2‐deficient) mice. The euglobulin clot lysis time (ELT) showed circadian
variations that peaked at 21: 00 (early night) in wild‐type mice, suggesting that fibrinolytic …