Effects of long-acting propranolol on AM and PM peaks in silent myocardial ischemia
PF Cohn, WE Lawson - The American journal of cardiology, 1989 - Elsevier
PF Cohn, WE Lawson
The American journal of cardiology, 1989•ElsevierThe frequency of episodes of silent myocardial ischemia and the adverse impact of these
episodes on cardiovascular morbidity and mortality have been demonstrated in several
studies involving both symptomatic and asymptomatic subjects. Previous reports using a
variety of agents—nitrates, 1 β blockers 2 and calcium antagonists 3—have shown the
efficacy of these drugs in reducing ischemic activity, but have not resolved the issue of
whether the circadian variation in ischemic events could be totally abolished. Beta blockers …
episodes on cardiovascular morbidity and mortality have been demonstrated in several
studies involving both symptomatic and asymptomatic subjects. Previous reports using a
variety of agents—nitrates, 1 β blockers 2 and calcium antagonists 3—have shown the
efficacy of these drugs in reducing ischemic activity, but have not resolved the issue of
whether the circadian variation in ischemic events could be totally abolished. Beta blockers …
Abstract
The frequency of episodes of silent myocardial ischemia and the adverse impact of these episodes on cardiovascular morbidity and mortality have been demonstrated in several studies involving both symptomatic and asymptomatic subjects. Previous reports using a variety of agents—nitrates,1 β blockers2 and calcium antagonists3—have shown the efficacy of these drugs in reducing ischemic activity, but have not resolved the issue of whether the circadian variation in ischemic events could be totally abolished. Beta blockers have been shown to be successful in blunting the a.m. peak, but there is little data concerning the P.M. peak. The present study was designed to test the hypothesis that β blockade with a long-acting propranolol preparation could abolish both a.m. and p.m. peaks in silent myocardial ischemic activity.
Elsevier