The effect of opioids on phantom limb pain and cortical reorganization
E Huse, W Larbig, H Flor, N Birbaumer - Pain, 2001 - Elsevier
The efficacy of oral retarded morphine sulphate (MST®) was tested against placebo in a
double-blind crossover design in 12 patients with phantom limb pain after unilateral leg or
arm amputation. Two counterbalanced treatment phases of 4 weeks each were initiated with
an intravenous test infusion of MST® or Placebo. The titration phase was 2 weeks. The dose
of MST® was titrated to at least 70 mg/day and at highest 300 mg/day. Pain intensity was
assessed hourly on visual analog scales during a 4-week treatment-free phase, both …
double-blind crossover design in 12 patients with phantom limb pain after unilateral leg or
arm amputation. Two counterbalanced treatment phases of 4 weeks each were initiated with
an intravenous test infusion of MST® or Placebo. The titration phase was 2 weeks. The dose
of MST® was titrated to at least 70 mg/day and at highest 300 mg/day. Pain intensity was
assessed hourly on visual analog scales during a 4-week treatment-free phase, both …