Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees
M Schley, S Topfner, K Wiech, HE Schaller… - European journal of …, 2007 - Elsevier
BACKGROUND: Hyperexcitability of N-methyl-d-aspartate acid (NMDA) receptors may play
an important role in the development of phantom limb pain (PLP). AIM OF THE STUDY: To
investigate whether early treatment with the NMDA antagonist memantine attenuates
phantom pain memory formation in traumatic amputees. METHODS: In a randomized,
double-blind, controlled trial 19 patients with acute traumatic amputation of the upper
extremity were investigated. All patients received postoperative analgesia by continuous …
an important role in the development of phantom limb pain (PLP). AIM OF THE STUDY: To
investigate whether early treatment with the NMDA antagonist memantine attenuates
phantom pain memory formation in traumatic amputees. METHODS: In a randomized,
double-blind, controlled trial 19 patients with acute traumatic amputation of the upper
extremity were investigated. All patients received postoperative analgesia by continuous …