[HTML][HTML] miR-125b suppresses proliferation and invasion by targeting MCL1 in gastric cancer
S Wu, F Liu, L Xie, Y Peng, X Lv, Y Zhu… - BioMed research …, 2015 - hindawi.com
S Wu, F Liu, L Xie, Y Peng, X Lv, Y Zhu, Z Zhang, X He
BioMed research international, 2015•hindawi.comUnderstanding the molecular mechanisms underlying gastric cancer progression
contributes to the development of novel targeted therapies. In this study, we found that the
expression levels of miR-125b were strongly downregulated in gastric cancer and
associated with clinical stage and the presence of lymph node metastases. Additionally, miR-
125b could independently predict OS and DFS in gastric cancer. We further found that
upregulation of miR-125b inhibited the proliferation and metastasis of gastric cancer cells in …
contributes to the development of novel targeted therapies. In this study, we found that the
expression levels of miR-125b were strongly downregulated in gastric cancer and
associated with clinical stage and the presence of lymph node metastases. Additionally, miR-
125b could independently predict OS and DFS in gastric cancer. We further found that
upregulation of miR-125b inhibited the proliferation and metastasis of gastric cancer cells in …
Understanding the molecular mechanisms underlying gastric cancer progression contributes to the development of novel targeted therapies. In this study, we found that the expression levels of miR-125b were strongly downregulated in gastric cancer and associated with clinical stage and the presence of lymph node metastases. Additionally, miR-125b could independently predict OS and DFS in gastric cancer. We further found that upregulation of miR-125b inhibited the proliferation and metastasis of gastric cancer cells in vitro and in vivo. miR-125b elicits these responses by directly targeting MCL1 (myeloid cell leukemia 1), which results in a marked reduction in MCL1 expression. Transfection of miR-125b sensitizes gastric cancer cells to 5-FU-induced apoptosis. By understanding the function and molecular mechanisms of miR-125b in gastric cancer, we may learn that miR-125b has the therapeutic potential to suppress gastric cancer progression and increase drug sensitivity to gastric cancer.
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