eIF2α is part of a multimeric complex that regulates cap-dependent translation.
Phosphorylation of eIF2α (phospho-eIF2α) is induced by various forms of cell stress,
resulting in changes to the proteome of the cell with two diametrically opposed
consequences, adaptation to stress or initiation of programmed cell death. In contrast to the
robust eIF2α phosphorylation seen in response to acute insults, less is known about the
functional role of basal levels of eIF2α phosphorylation. Here we show that mouse …