A novel transcription mechanism activated by ethanol: induction of Slc7a11 gene expression via inhibition of the DNA-binding activity of transcriptional repressor …
X Lin, H Yang, H Zhang, LC Zhou, ZM Guo - Journal of Biological Chemistry, 2013 - ASBMB
Solute carrier family 7, member 11 (Slc7a11) is a plasma membrane cystine/glutamate
exchanger that provides intracellular cystine to produce glutathione, a major cellular
antioxidant. Oxidative and endoplasmic reticulum stresses up-regulate Slc7a11 expression
by activation of nuclear factor erythroid 2-related factor 2 and transcription factor 4. This
study examined the effect of ethanol on Slc7a11 expression and the underlying mechanism
involved. Treatment of mouse hepatic stellate cells with ethanol significantly increased …
exchanger that provides intracellular cystine to produce glutathione, a major cellular
antioxidant. Oxidative and endoplasmic reticulum stresses up-regulate Slc7a11 expression
by activation of nuclear factor erythroid 2-related factor 2 and transcription factor 4. This
study examined the effect of ethanol on Slc7a11 expression and the underlying mechanism
involved. Treatment of mouse hepatic stellate cells with ethanol significantly increased …
