Changes in glutathione homeostasis during liver regeneration in the rat
ZZ Huang, H Li, J Cai, J Kuhlenkamp, N Kaplowitz… - Hepatology, 1998 - journals.lww.com
We have shown previously that plating primary cultures of rat hepatocytes under low density,
which stimulates hepatocytes to shift from the G 0 to the G 1 phase of the cell cycle, resulted
in increased levels of glutathione (GSH) and cysteine, and increased activity of γ-
glutamylcysteine synthetase (GCS), the rate-limiting enzyme in GSH synthesis (Lu et al., Am.
J. Physiol. 1992; 263: C1181-C1189). In the current work we examined changes in GSH
homeostasis after two-thirds partial hepatectomy (PH). Male Sprague-Dawley rats …
which stimulates hepatocytes to shift from the G 0 to the G 1 phase of the cell cycle, resulted
in increased levels of glutathione (GSH) and cysteine, and increased activity of γ-
glutamylcysteine synthetase (GCS), the rate-limiting enzyme in GSH synthesis (Lu et al., Am.
J. Physiol. 1992; 263: C1181-C1189). In the current work we examined changes in GSH
homeostasis after two-thirds partial hepatectomy (PH). Male Sprague-Dawley rats …
