Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor–related apoptosis-inducing ligand
L Zhuang, CS Lee, RA Scolyer, SW McCarthy… - Human pathology, 2006 - Elsevier
Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces apoptosis in
melanoma by interaction with death receptors TRAIL-R1 (DR4) or TRAIL-R2 (DR5) on
melanoma cells or resists apoptosis by interaction with decoy receptors TRAIL-R3 (DcR1) or
TRAIL-R4 (DcR2). Studies on cell lines suggest that there is a wide variation in TRAIL death
receptor expression; however, their expression on excised human melanoma is not well
documented. In view of this, we studied death receptor expression on melanomas using …
melanoma by interaction with death receptors TRAIL-R1 (DR4) or TRAIL-R2 (DR5) on
melanoma cells or resists apoptosis by interaction with decoy receptors TRAIL-R3 (DcR1) or
TRAIL-R4 (DcR2). Studies on cell lines suggest that there is a wide variation in TRAIL death
receptor expression; however, their expression on excised human melanoma is not well
documented. In view of this, we studied death receptor expression on melanomas using …