[HTML][HTML] Suppression of lipopolysaccharide-stimulated tumor necrosis factor-α production by adiponectin is mediated by transcriptional and post-transcriptional …
PH Park, H Huang, MR McMullen, P Mandal… - Journal of Biological …, 2008 - ASBMB
Adiponectin is an adipokine with potent anti-inflammatory properties. Treatment of
macrophages with adiponectin results in a suppression of lipopolysaccharide (LPS)-
stimulated cytokine production. Here we investigated the transcriptional and post-
transcriptional mechanisms by which adiponectin suppresses LPS-stimulated tumor
necrosis factor (TNF)-α production. Treatment of RAW 264.7 macrophages with LPS
increased TNF-α promoter-driven luciferase activity (TNF-α promoter/Luc activity) by 20-fold …
macrophages with adiponectin results in a suppression of lipopolysaccharide (LPS)-
stimulated cytokine production. Here we investigated the transcriptional and post-
transcriptional mechanisms by which adiponectin suppresses LPS-stimulated tumor
necrosis factor (TNF)-α production. Treatment of RAW 264.7 macrophages with LPS
increased TNF-α promoter-driven luciferase activity (TNF-α promoter/Luc activity) by 20-fold …