Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis
M Wang, M Halasi, K Kabirov, A Banerjee, J Landolfi… - Cell Cycle, 2012 - Taylor & Francis
M Wang, M Halasi, K Kabirov, A Banerjee, J Landolfi, AV Lyubimov, AL Gartel
Cell Cycle, 2012•Taylor & FrancisNanoparticle-encapsulated thiazole antibiotic, thiostrepton, has been shown to be an
effective agent for inhibiting tumor growth in solid tumor models through the inhibition of
proteasomal activity by the induction of apoptosis in cancer cells. Here, we show the efficacy
of thiostrepton-micelles in inhibiting tumor growth in a DEN/PB-induced liver cancer model.
We also demonstrate an enhanced anticancer effect of the combination treatment of
thiostrepton with bortezomib, another proteasome inhibitor in this liver cancer model.
effective agent for inhibiting tumor growth in solid tumor models through the inhibition of
proteasomal activity by the induction of apoptosis in cancer cells. Here, we show the efficacy
of thiostrepton-micelles in inhibiting tumor growth in a DEN/PB-induced liver cancer model.
We also demonstrate an enhanced anticancer effect of the combination treatment of
thiostrepton with bortezomib, another proteasome inhibitor in this liver cancer model.
Nanoparticle-encapsulated thiazole antibiotic, thiostrepton, has been shown to be an effective agent for inhibiting tumor growth in solid tumor models through the inhibition of proteasomal activity by the induction of apoptosis in cancer cells. Here, we show the efficacy of thiostrepton-micelles in inhibiting tumor growth in a DEN/PB-induced liver cancer model. We also demonstrate an enhanced anticancer effect of the combination treatment of thiostrepton with bortezomib, another proteasome inhibitor in this liver cancer model.
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