[HTML][HTML] Intranodal interaction with dendritic cells dynamically regulates surface expression of the co-stimulatory receptor CD226 protein on murine T cells

S Seth, Q Qiu, S Danisch, MK Maier, A Braun… - Journal of Biological …, 2011 - ASBMB
Dendritic cells (DCs) are the most potent antigen-presenting cells of the immune system.
Depending on their maturation status, they prime T cells to induce adaptive immunity or
tolerance. DCs express CD155, an immunoglobulin-like receptor binding CD226 present on
T and natural killer (NK) cells. CD226 represents an important co-stimulator during T cell
priming but also serves as an activating receptor on cytotoxic T and NK cells. Here, we
report that cells of the T and NK cell lineage of CD155−/− mice express markedly elevated …