[HTML][HTML] Many ceramides

YA Hannun, LM Obeid - Journal of Biological Chemistry, 2011 - ASBMB
Intensive research over the past 2 decades has implicated ceramide in the regulation of
several cell responses. However, emerging evidence points to dramatic complexities in
ceramide metabolism and structure that defy the prevailing unifying hypothesis on ceramide
function that is based on the understanding of ceramide as a single entity. Here, we develop
the concept that" ceramide" constitutes a family of closely related molecules, subject to
metabolism by> 28 enzymes and with> 200 structurally distinct mammalian ceramides …