[HTML][HTML] Ceramide stabilizes β-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid β-peptide biogenesis
L Puglielli, BC Ellis, AJ Saunders, DM Kovacs - Journal of Biological …, 2003 - ASBMB
The lipid second messenger ceramide regulates several biochemical events that occur
during aging. In addition, its level is highly elevated in the amyloid-burdened brains of
Alzheimer's disease patients. Here, we analyzed the impact of aberrant ceramide levels on
amyloid β-peptide (Aβ) generation by using a cell-permeable analog of ceramide, C6-
ceramide, and several biochemical inhibitors of the sphingomyelin/glycosphingolipid
biosynthetic pathway. We found that C6-ceramide increased the biogenesis of Aβ by …
during aging. In addition, its level is highly elevated in the amyloid-burdened brains of
Alzheimer's disease patients. Here, we analyzed the impact of aberrant ceramide levels on
amyloid β-peptide (Aβ) generation by using a cell-permeable analog of ceramide, C6-
ceramide, and several biochemical inhibitors of the sphingomyelin/glycosphingolipid
biosynthetic pathway. We found that C6-ceramide increased the biogenesis of Aβ by …