Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging
SA Lightle, JI Oakley… - Mechanisms of ageing …, 2000 - Elsevier
Aging leads to a decreased ability of liver to metabolize drugs and increased expression
and secretion of acute phase proteins, such as serum amyloid A (SAA), C-reactive protein
(CRP), and alpha-1-acid glycoprotein (AGP). This phenomenon resembles some aspects of
the acute phase response of host to inflammation; however, the molecular basis for the
similarity is unclear. Ceramide and sphingosine are second messenger mediators of cellular
responses to stress and inflammation. In liver, they play important role in mediating acute …
and secretion of acute phase proteins, such as serum amyloid A (SAA), C-reactive protein
(CRP), and alpha-1-acid glycoprotein (AGP). This phenomenon resembles some aspects of
the acute phase response of host to inflammation; however, the molecular basis for the
similarity is unclear. Ceramide and sphingosine are second messenger mediators of cellular
responses to stress and inflammation. In liver, they play important role in mediating acute …