Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy
PF Giannopoulos, J Chu, M Sperow, JG Li, WH Yu… - Biological …, 2015 - Elsevier
Abstract Background 5-Lipoxygenase (5-LO) is a protein widely distributed in the central
nervous system where it modulates amyloidosis and memory impairments in transgenic
mouse models of Alzheimer's disease. However, no data are available as to whether 5-LO is
elevated in human tauopathy or if it directly influences tau pathology in a relevant model of
the disease. Methods We assayed 5-LO levels in brain samples from patients with tauopathy
and transgenic tau mice, and we evaluated the effect of 5-LO pharmacologic inhibition on …
nervous system where it modulates amyloidosis and memory impairments in transgenic
mouse models of Alzheimer's disease. However, no data are available as to whether 5-LO is
elevated in human tauopathy or if it directly influences tau pathology in a relevant model of
the disease. Methods We assayed 5-LO levels in brain samples from patients with tauopathy
and transgenic tau mice, and we evaluated the effect of 5-LO pharmacologic inhibition on …