Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma

T Koshino, S Takano, S Kitani, N Ohshima… - Molecular Cell Biology …, 1999 - Elsevier
The human 5-lipoxygenase activating protein (FLAP) gene is one of the key genes involved
in the production of the cysteinyl-leukotrienes. We studied novel polymorphism of the FLAP
promoter gene and attempted to clarify the relationship between this polymorphism and
asthma. We sequenced the FLAP promoter region, containing the− 170 to+ 46-bp sequence
from the translational start codon, and found two homozygotes of novel alleles in the
polyadenyl region which showed 21 A repeats and 18 A repeats, respectively. The …