Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes
BK Lam, KF Austen - Prostaglandins & other lipid mediators, 2002 - Elsevier
Leukotriene C4 synthase (LTC4S) conjugates LTA4 with glutathione (GSH) to form LTC4,
the parent compound of the cysteinyl LTs. LTC4S is an 18kDa membrane protein and
functions as a noncovalent homodimer. The enzyme activity of LTC4S is augmented by
Mg2+ and inhibited by Co2+ and the function of 5-lipoxygenase (LO) activating protein
(FLAP) inhibitor MK-886. The Km and Vmax values are 3.6 μM and 1.3 μmol/mg/min for
LTA4 and 1.6 mM and 2.7 μmol/mg/min for GSH, respectively. The deduced amino acid …
the parent compound of the cysteinyl LTs. LTC4S is an 18kDa membrane protein and
functions as a noncovalent homodimer. The enzyme activity of LTC4S is augmented by
Mg2+ and inhibited by Co2+ and the function of 5-lipoxygenase (LO) activating protein
(FLAP) inhibitor MK-886. The Km and Vmax values are 3.6 μM and 1.3 μmol/mg/min for
LTA4 and 1.6 mM and 2.7 μmol/mg/min for GSH, respectively. The deduced amino acid …