[HTML][HTML] Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase

Y Kanaoka, A Maekawa, JF Penrose, KF Austen… - Journal of Biological …, 2001 - ASBMB
Leukotriene C 4 synthase (LTC 4 S), the terminal 5-lipoxygenase pathway enzyme that is
responsible for the biosynthesis of cysteinyl leukotrienes, has been deleted by targeted
gene disruption to define its tissue distribution and integrated pathway function in vitro and
in vivo. The LTC 4 S−/− mice developed normally and were fertile. LTC 4 S activity,
assessed by conjugation of leukotriene (LT) A 4 methyl ester with glutathione, was absent
from tongue, spleen, and brain and≥ 90% reduced in lung, stomach, and colon of the LTC 4 …