[HTML][HTML] Membrane localization and topology of leukotriene C4 synthase
P Christmas, BM Weber, M McKee, D Brown… - Journal of Biological …, 2002 - ASBMB
Leukotriene C 4 (LTC 4) synthase conjugates LTA 4 with GSH to form LTC 4. Determining
the site of LTC 4 synthesis and the topology of LTC 4 synthase may uncover unappreciated
intracellular roles for LTC 4, as well as how LTC 4 is transferred to its export carrier, the
multidrug resistance protein-1. We have determined the membrane localization of LTC 4
synthase by immunoelectron microscopy. In contrast to the closely related five-lipoxygenase-
activating protein, LTC 4 synthase is distributed in the outer nuclear membrane and …
the site of LTC 4 synthesis and the topology of LTC 4 synthase may uncover unappreciated
intracellular roles for LTC 4, as well as how LTC 4 is transferred to its export carrier, the
multidrug resistance protein-1. We have determined the membrane localization of LTC 4
synthase by immunoelectron microscopy. In contrast to the closely related five-lipoxygenase-
activating protein, LTC 4 synthase is distributed in the outer nuclear membrane and …