The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

CN Serhan, N Chiang, J Dalli - Seminars in immunology, 2015 - Elsevier
Seminars in immunology, 2015Elsevier
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro-
resolving mediators (SPM) including lipoxins, resolvins, protectins and maresins that are
each temporally produced by resolving-exudates with distinct actions for return to
homeostasis. SPM evoke potent anti-inflammatory and novel pro-resolving mechanisms as
well as enhance microbial clearance. While born in inflammation-resolution, SPM are …
Abstract
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro-resolving mediators (SPM) including lipoxins, resolvins, protectins and maresins that are each temporally produced by resolving-exudates with distinct actions for return to homeostasis. SPM evoke potent anti-inflammatory and novel pro-resolving mechanisms as well as enhance microbial clearance. While born in inflammation-resolution, SPM are conserved structures with functions discovered in microbial defense, pain, organ protection and tissue regeneration, wound healing, cancer, reproduction, and neurobiology-cognition. This review covers these SPM mechanisms and other new omega-3 PUFA pathways that open their path for functions in resolution physiology.
Elsevier