[HTML][HTML] Dendritic cell-based immunotherapy

RL Sabado, S Balan, N Bhardwaj - Cell research, 2017 - nature.com
RL Sabado, S Balan, N Bhardwaj
Cell research, 2017nature.com
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for
harnessing the potential of a patient's own immune system to eliminate tumor cells in
metastatic hormone-refractory cancer. Overall, although many DC vaccines have been
tested in the clinic and proven to be immunogenic, and in some cases associated with
clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this
review we will discuss what has been learned thus far about human DC biology from clinical …
Abstract
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.
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