Recent progress in phospholipase A2 research: from cells to animals to humans

M Murakami, Y Taketomi, Y Miki, H Sato… - Progress in lipid …, 2011 - Elsevier
Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight
secreted PLA2s (sPLA2s), Ca2+-dependent cytosolic PLA2s (cPLA2s), Ca2+-independent
PLA2s (iPLA2s), platelet-activating factor acetylhydrolases (PAF-AHs), lysosomal PLA2s,
and a recently identified adipose-specific PLA. Of these, the intracellular cPLA2 and iPLA2
families and the extracellular sPLA2 family are recognized as the “big three”. From a general …