The expression of calcitonin gene-related peptide in dorsal horn neurons of the mouse lumbar spinal cord

SS Tie-Jun, Z Xu, T Hökfelt - Neuroreport, 2001 - journals.lww.com
Using immunohistochemistry and in situ hybridization the expression of calcitonin gene-
related peptide (CGRP) was studied in the mouse spinal cord under normal conditions and
after unilateral rhizotomy and after local colchicine treatment. Under normal conditions a
dense plexus of CGRP-immunoreactive (IR) fibres was observed in the superfical layers of
dorsal horns with lower numbers of fibers in deeper laminae. Seven days after unilateral
rhizotomy, there was a marked reduction of CGRP-IR fibres in the ipsilateral superfical …