The NLRP3 inflammasome promotes renal inflammation and contributes to CKD

A Vilaysane, J Chun, ME Seamone… - Journal of the …, 2010 - journals.lww.com
Inflammation significantly contributes to the progression of chronic kidney disease (CKD).
Inflammasome-dependent cytokines, such as IL-1β and IL-18, play a role in CKD, but their
regulation during renal injury is unknown. Here, we analyzed the processing of caspase-1,
IL-1β, and IL-18 after unilateral ureteral obstruction (UUO) in mice, which suggested
activation of the Nlrp3 inflammasome during renal injury. Compared with wild-type mice,
Nlrp3−/− mice had less tubular injury, inflammation, and fibrosis after UUO, associated with …