NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

J Tschopp, K Schroder - Nature reviews immunology, 2010 - nature.com
J Tschopp, K Schroder
Nature reviews immunology, 2010nature.com
The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein
complex that activates caspase 1, leading to the processing and secretion of the pro-
inflammatory cytokines interleukin-1β (IL-1β) and IL-18. The NLRP3 inflammasome is
activated by a wide range of danger signals that derive not only from microorganisms but
also from metabolic dysregulation. It is unclear how these highly varied stress signals can be
detected by a single inflammasome. In this Opinion article, we review the different signalling …
Abstract
The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS).
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