Pharmacological preconditioning of random-pattern skin flaps with local FK506 in nicotine-treated rats: interaction with nitric oxide system
BG Nezami, S Rahimpour, S Sianati… - Journal of Plastic …, 2009 - jprasurg.com
We have previously shown that FK-506 (tacrolimus) improves random-pattern skin flap
survival in normal animals. 1 Skin flap survival is decreased in cigarette smokers,
presumably by perturbing endothelial function and tissue viability. Nicotine, as the mediator
of this effect, impairs endothelium-dependent relaxation, which is thought to result from the
reduction in nitric oxide (NO) production and eNOS mRNA expression in exposed vessels. 2
In addition, subsequent ischaemia after raising the flap generates excessive amounts of …
survival in normal animals. 1 Skin flap survival is decreased in cigarette smokers,
presumably by perturbing endothelial function and tissue viability. Nicotine, as the mediator
of this effect, impairs endothelium-dependent relaxation, which is thought to result from the
reduction in nitric oxide (NO) production and eNOS mRNA expression in exposed vessels. 2
In addition, subsequent ischaemia after raising the flap generates excessive amounts of …