[HTML][HTML] Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex

Y Gore, D Starlets, N Maharshak… - Journal of Biological …, 2008 - ASBMB
Macrophage migration inhibitory factor (MIF) is an upstream activator of innate immunity that
regulates subsequent adaptive responses. It was previously shown that in macrophages,
MIF binds to a complex of CD74 and CD44, resulting in initiation of a signaling pathway. In
the current study, we investigated the role of MIF in B cell survival. We show that in B
lymphocytes, MIF initiates a signaling cascade that involves Syk and Akt, leading to NF-κB
activation, proliferation, and survival in a CD74-and CD44-dependent manner. Thus, MIF …