Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer
MS Reimers, E Bastiaannet, RE Langley… - JAMA internal …, 2014 - jamanetwork.com
Importance Use of aspirin (which inhibits platelet function) after a colon cancer diagnosis is
associated with improved overall survival. Identifying predictive biomarkers of this effect
could individualize therapy and decrease toxic effects. Objective To demonstrate that
survival benefit associated with low-dose aspirin use after a diagnosis of colorectal cancer
might depend on HLA class I antigen expression. Design, Setting, and Participants A cohort
study with tumor blocks from 999 patients with colon cancer (surgically resected between …
associated with improved overall survival. Identifying predictive biomarkers of this effect
could individualize therapy and decrease toxic effects. Objective To demonstrate that
survival benefit associated with low-dose aspirin use after a diagnosis of colorectal cancer
might depend on HLA class I antigen expression. Design, Setting, and Participants A cohort
study with tumor blocks from 999 patients with colon cancer (surgically resected between …