Non-apoptotic Fas signaling
H Wajant, K Pfizenmaier, P Scheurich - Cytokine & growth factor reviews, 2003 - Elsevier
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor
and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic
processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune
privilege and tumor surveillance. Impairment of the FasL/Fas system has been implicated in
liver failure, autoimmune diseases and immune deficiency. Thus, the FasL/Fas system was
mainly appreciated with respect to its death-inducing capabilities. However, there is …
and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic
processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune
privilege and tumor surveillance. Impairment of the FasL/Fas system has been implicated in
liver failure, autoimmune diseases and immune deficiency. Thus, the FasL/Fas system was
mainly appreciated with respect to its death-inducing capabilities. However, there is …