Diesel exhaust particulate induces airway hyperresponsiveness in a murine model: essential role of GM-CSF
K Ohta, N Yamashita, M Tajima, T Miyasaka… - Journal of Allergy and …, 1999 - Elsevier
Background: Inhaled pollutants were recently shown to be responsible for an increased
incidence of airway allergic diseases, including asthma. A common feature of all forms of
asthma is airway hyperresponsiveness. Objective: Our purpose was to elucidate the effects
of diesel exhaust particulate (DEP), one of the most prevalent inhaled pollutants, on airway
responsiveness. Methods: A/J and C57Bl/6 mice were used; the former are genetically
predisposed to be hyperresponsive to acetylcholine, whereas the latter are not. DEP was …
incidence of airway allergic diseases, including asthma. A common feature of all forms of
asthma is airway hyperresponsiveness. Objective: Our purpose was to elucidate the effects
of diesel exhaust particulate (DEP), one of the most prevalent inhaled pollutants, on airway
responsiveness. Methods: A/J and C57Bl/6 mice were used; the former are genetically
predisposed to be hyperresponsive to acetylcholine, whereas the latter are not. DEP was …