Leukotriene D4 receptor antagonism reduces airway hyperresponsiveness in monkeys
CR Turner, WB Smith, CJ Andresen, AC Swindell… - Pulmonary …, 1994 - Elsevier
Airway hyperresponsiveness (AHR) and pulmonary inflammation are observations that are
consistently associated with asthma and also occur in a well-characterized monkey model of
asthma. The following study was performed to determine whether treatment with an LTD 4
receptor antagonist, ICI 198,615, could attenuate antigen-induced pulmonary inflammation
and AHR in monkeys using the following protocol. On day 0, the PC 200 (the concentration
of methacholine (MCh) that doubled respiratory system resistance, R rs) was determined in …
consistently associated with asthma and also occur in a well-characterized monkey model of
asthma. The following study was performed to determine whether treatment with an LTD 4
receptor antagonist, ICI 198,615, could attenuate antigen-induced pulmonary inflammation
and AHR in monkeys using the following protocol. On day 0, the PC 200 (the concentration
of methacholine (MCh) that doubled respiratory system resistance, R rs) was determined in …