Mast cell–dependent migration of effector CD8+ T cells through production of leukotriene B4

VL Ott, JC Cambier, J Kappler, P Marrack… - Nature …, 2003 - nature.com
VL Ott, JC Cambier, J Kappler, P Marrack, BJ Swanson
Nature immunology, 2003nature.com
Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic
inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to
inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is
known. Here we report that activated mast cells induced chemotaxis of effector, but not
central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies
indicate that LTB4 production by activated peripheral leukocytes could be important for the …
Abstract
Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation.
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