[HTML][HTML] A novel hepatointestinal leukotriene B4 receptor: cloning and functional characterization
S Wang, E Gustafson, L Pang, X Qiao, J Behan… - Journal of Biological …, 2000 - ASBMB
Leukotriene B 4 (LTB 4) is a product of eicosanoid metabolism and acts as an extremely
potent chemotactic mediator for inflammation. LTB 4 exerts positive effects on the
immigration and activation of leukocytes. These effects suggest an involvement of LTB 4 in
several diseases: inflammatory bowel disease, psoriasis, arthritis, and asthma. LTB 4 elicits
actions through interaction with one or more cell surface receptors that lead to chemotaxis
and inflammation. One leukotriene B 4 receptor has been recently identified (LTB 4-R1). In …
potent chemotactic mediator for inflammation. LTB 4 exerts positive effects on the
immigration and activation of leukocytes. These effects suggest an involvement of LTB 4 in
several diseases: inflammatory bowel disease, psoriasis, arthritis, and asthma. LTB 4 elicits
actions through interaction with one or more cell surface receptors that lead to chemotaxis
and inflammation. One leukotriene B 4 receptor has been recently identified (LTB 4-R1). In …