[HTML][HTML] Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes
Y Iizuka, T Yokomizo, K Terawaki, M Komine… - Journal of Biological …, 2005 - ASBMB
Leukotriene B4 (LTB4) is a potent chemoattractant and activator for granulocytes and
macrophages and is considered to be an inflammatory mediator. Two G-protein-coupled
receptors for LTB4, BLT1 and BLT2, have been cloned from human and shown to be high
and low affinity LTB4 receptors, respectively. To reveal the biological roles of BLT2 using
mouse disease models, we cloned and characterized mouse BLT2. Chinese hamster ovary
cells stably expressing mouse BLT2 exhibited specific binding to LTB4, LTB4-induced …
macrophages and is considered to be an inflammatory mediator. Two G-protein-coupled
receptors for LTB4, BLT1 and BLT2, have been cloned from human and shown to be high
and low affinity LTB4 receptors, respectively. To reveal the biological roles of BLT2 using
mouse disease models, we cloned and characterized mouse BLT2. Chinese hamster ovary
cells stably expressing mouse BLT2 exhibited specific binding to LTB4, LTB4-induced …