Arachidonic acid is metabolized by two major pathways, cyclooxygenases and
lipoxygenases. The metabolites catalyzed by these enzymes are important mediators of
acute and chronic inflammation. Both enzymes and their metabolites are well recognized to
be involved in cancer development and progress. It is well documented that inhibition of
cyclooxygenase 2 (COX-2) activity decreases cancer incidence and inhibits tumor growth. It
has also been reported that 5-lipoxygenase is involved in cancer cell survival and …