[PDF][PDF] The HECT family of E3 ubiquitin ligases: multiple players in cancer development

F Bernassola, M Karin, A Ciechanover, G Melino - Cancer cell, 2008 - cell.com
Cancer cell, 2008cell.com
The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial
signaling pathways implicated in tumorigenesis is presently an area of intense research and
extensive scientific interest. This review highlights recent discoveries on the ubiquitin-
mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type
E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity
of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the …
The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.
cell.com