Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways

F Mattiroli, TK Sixma - Nature structural & molecular biology, 2014 - nature.com
Nature structural & molecular biology, 2014nature.com
Ubiquitin and ubiquitin-like modifications are central to virtually all cellular signaling
pathways. They occur primarily on lysine residues of target proteins and stimulate a large
number of downstream signals. The diversity of these signals depends on the type, location
and dynamics of the modification, but the role of the exact site of modification and the
selectivity for specific lysines are poorly understood. Here we review the current literature on
lysine specificity in these modifications, and we highlight the known signaling mechanisms …
Abstract
Ubiquitin and ubiquitin-like modifications are central to virtually all cellular signaling pathways. They occur primarily on lysine residues of target proteins and stimulate a large number of downstream signals. The diversity of these signals depends on the type, location and dynamics of the modification, but the role of the exact site of modification and the selectivity for specific lysines are poorly understood. Here we review the current literature on lysine specificity in these modifications, and we highlight the known signaling mechanisms and the open questions that pose future challenges to ubiquitin research.
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