[HTML][HTML] The 26 S proteasome: from basic mechanisms to drug targeting
A Navon, A Ciechanover - Journal of Biological Chemistry, 2009 - ASBMB
The regulated degradation of proteins within eukaryotes and bacterial cells is catalyzed
primarily by large multimeric proteases in ATP-dependent manner. In eukaryotes, the 26 S
proteasome is essential for the rapid destruction of key regulatory proteins, such as cell
cycle regulators and transcription factors, whose fast and tuned elimination is necessary for
the proper control of the fundamental cell processes they regulate. In addition, the 26 S
proteasome is responsible for cell quality control by eliminating defective proteins from the …
primarily by large multimeric proteases in ATP-dependent manner. In eukaryotes, the 26 S
proteasome is essential for the rapid destruction of key regulatory proteins, such as cell
cycle regulators and transcription factors, whose fast and tuned elimination is necessary for
the proper control of the fundamental cell processes they regulate. In addition, the 26 S
proteasome is responsible for cell quality control by eliminating defective proteins from the …