Human sepsis eicosanoid and proresolving lipid mediator temporal profiles: correlations with survival and clinical outcomes
Objective: To identify and measure recently described chemical mediators, termed
specialized pro-resolving mediators that actively regulate the resolution of acute-
inflammation, and correlate measurements with clinical outcomes. Design: Herein,
deidentified plasma was collected from sepsis patients (n= 22 subjects) within 48 hours of
admission to the ICU and on days 3 and 7 thereafter and subjected to lipid mediator
profiling. Setting: Brigham and Women's Hospital Medical Intensive Care Unit. Subjects …
specialized pro-resolving mediators that actively regulate the resolution of acute-
inflammation, and correlate measurements with clinical outcomes. Design: Herein,
deidentified plasma was collected from sepsis patients (n= 22 subjects) within 48 hours of
admission to the ICU and on days 3 and 7 thereafter and subjected to lipid mediator
profiling. Setting: Brigham and Women's Hospital Medical Intensive Care Unit. Subjects …