[HTML][HTML] Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions
The resolvins (Rv) are lipid mediators derived from omega-3 polyunsaturated fatty acids that
act within a local inflammatory milieu to stop leukocyte recruitment and promote resolution.
Resolvin E1 (RvE1;(5S, 12R, 18R)-trihydroxy-6Z, 8E, 10E, 14Z, 16E-eicosapentaenoic acid)
is an oxygenase product derived from omega-3 eicosapentaenoic acid that displays potent
anti-inflammation/pro-resolution actions in vivo. Here, we determined whether
oxidoreductase enzymes catalyze the conversion of RvE1 and assessed the biological …
act within a local inflammatory milieu to stop leukocyte recruitment and promote resolution.
Resolvin E1 (RvE1;(5S, 12R, 18R)-trihydroxy-6Z, 8E, 10E, 14Z, 16E-eicosapentaenoic acid)
is an oxygenase product derived from omega-3 eicosapentaenoic acid that displays potent
anti-inflammation/pro-resolution actions in vivo. Here, we determined whether
oxidoreductase enzymes catalyze the conversion of RvE1 and assessed the biological …