[HTML][HTML] Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in …
The lipoxins (LX) are autacoids that act within a local inflammatory milieu to dampen
neutrophil recruitment and promote resolution. 15-Hydroxyprostaglandin dehydrogenase
(15-PGDH) and 15-oxoprostaglandin 13-reductase, also termed leukotriene B 4 12-
hydroxydehydrogenase (PGR/LTB 4 DH), are two enzymatic activities appreciated for their
roles in the metabolism of prostaglandins and LTB 4. Here, we determined whether these
oxidoreductases also catalyze the conversion of lipoxin A 4 (LXA 4) and assessed the …
neutrophil recruitment and promote resolution. 15-Hydroxyprostaglandin dehydrogenase
(15-PGDH) and 15-oxoprostaglandin 13-reductase, also termed leukotriene B 4 12-
hydroxydehydrogenase (PGR/LTB 4 DH), are two enzymatic activities appreciated for their
roles in the metabolism of prostaglandins and LTB 4. Here, we determined whether these
oxidoreductases also catalyze the conversion of lipoxin A 4 (LXA 4) and assessed the …