Dexmedetomidine prevents cognitive decline by enhancing resolution of high mobility group box 1 protein–induced inflammation through a vagomimetic action in …
Background Inflammation initiated by damage-associated molecular patterns has been
implicated for the cognitive decline associated with surgical trauma and serious illness. We
determined whether resolution of inflammation mediates dexmedetomidine-induced
reduction of damage-associated molecular pattern–induced cognitive decline. Methods
Cognitive decline (assessed by trace fear conditioning) was induced with high molecular
group box 1 protein, a damage-associated molecular pattern, in mice that also received …
implicated for the cognitive decline associated with surgical trauma and serious illness. We
determined whether resolution of inflammation mediates dexmedetomidine-induced
reduction of damage-associated molecular pattern–induced cognitive decline. Methods
Cognitive decline (assessed by trace fear conditioning) was induced with high molecular
group box 1 protein, a damage-associated molecular pattern, in mice that also received …