Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity?
CN Serhan - Prostaglandins, 1997 - Elsevier
Lipid-derived mediators play critical roles in inflammation and other multicellular vascular
processes, including atherosclerosis and thrombosis (1). The lipoxins (LXs) were first
isolated in 1984 (2), and have continued to show intriguing and potentially important
biological roles. These compounds carry a trihydroxytetraene structure and are both
structurally and functionally unique among arachidonic acid-derived bioactive products (Fig.
1). The availability of synthetic materials for evaluation of bioactions as well as appropriate …
processes, including atherosclerosis and thrombosis (1). The lipoxins (LXs) were first
isolated in 1984 (2), and have continued to show intriguing and potentially important
biological roles. These compounds carry a trihydroxytetraene structure and are both
structurally and functionally unique among arachidonic acid-derived bioactive products (Fig.
1). The availability of synthetic materials for evaluation of bioactions as well as appropriate …