[HTML][HTML] Novel n-3 immunoresolvents: structures and actions

J Dalli, RA Colas, CN Serhan - Scientific reports, 2013 - nature.com
Scientific reports, 2013nature.com
Resolution of inflammation is now held to be an active process where autacoids promote
homeostasis. Using functional-metabololipidomics and in vivo systems, herein we report that
endogenous n-3 docosapentaenoic (DPA) acid is converted during inflammation-resolution
in mice and by human leukocytes to novel n-3 products congenerous to D-series resolvins
(Rv), protectins (PD) and maresins (MaR), termed specialized pro-resolving mediators
(SPM). The new n-3 DPA structures include 7, 8, 17-trihydroxy-9, 11, 13, 15 E, 19 Z …
Abstract
Resolution of inflammation is now held to be an active process where autacoids promote homeostasis. Using functional-metabololipidomics and in vivo systems, herein we report that endogenous n-3 docosapentaenoic (DPA) acid is converted during inflammation-resolution in mice and by human leukocytes to novel n-3 products congenerous to D-series resolvins (Rv), protectins (PD) and maresins (MaR), termed specialized pro-resolving mediators (SPM). The new n-3 DPA structures include 7,8,17-trihydroxy-9,11,13,15E,19Z-docosapentaenoic acid (RvD1n-3 DPA), 7,14-dihydroxy-8,10,12,16Z,19Z-docosapentaenoic acid (MaR1n-3 DPA) and related bioactive products. Each n-3 DPA-SPM displayed protective actions from second organ injury and reduced systemic inflammation in ischemia-reperfusion. The n-3 DPA-SPM, including RvD1n-3 DPA and MaR1n-3 DPA, each exerted potent leukocyte directed actions in vivo. With human leukocytes each n-3 DPA-SPM reduced neutrophil chemotaxis, adhesion and enhanced macrophage phagocytosis. Together, these findings demonstrate that n-3 DPA is converted to novel immunoresolvents with actions comparable to resolvins and are likely produced in humans when n-3 DPA is elevated.
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