[HTML][HTML] A new era of secreted phospholipase A2

M Murakami, H Sato, Y Miki, K Yamamoto… - Journal of lipid …, 2015 - ASBMB
Among more than 30 members of the phospholipase A 2 (PLA 2) superfamily, secreted PLA
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular-
weight enzymes with a His-Asp catalytic dyad. Individual sPLA 2 s exhibit unique tissue and
cellular distributions and enzymatic properties, suggesting their distinct biological roles.
Recent studies using transgenic and knockout mice for nearly a full set of sPLA 2 subtypes,
in combination with sophisticated lipidomics as well as biochemical and cell biological …