Synaptopodin is a coincidence detector of tyrosine versus serine/threonine phosphorylation for the modulation of rho protein crosstalk in podocytes
L Buvall, H Wallentin, J Sieber… - Journal of the …, 2017 - journals.lww.com
Tyrosine and serine/threonine signal-transduction pathways influence many aspects of cell
behavior, including the spatial and temporal regulation of the actin cytoskeleton. However,
little is known about how input from diverse tyrosine and serine/threonine kinases is
integrated to control Rho protein crosstalk and actin remodeling, which are critically
important in podocyte health and disease. Here we unveil the proteolytically-regulated, actin
organizing protein synaptopodin as a coincidence detector of tyrosine versus …
behavior, including the spatial and temporal regulation of the actin cytoskeleton. However,
little is known about how input from diverse tyrosine and serine/threonine kinases is
integrated to control Rho protein crosstalk and actin remodeling, which are critically
important in podocyte health and disease. Here we unveil the proteolytically-regulated, actin
organizing protein synaptopodin as a coincidence detector of tyrosine versus …