[HTML][HTML] The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells
DNA CpG methylation can cooperate with histone H3 lysine 9 (H3-K9) methylation in
heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently
identified euchromatic histone methyltransferase SETDB1/ESET may be responsible for
transcriptional repression of certain promoters. Here, we show that SETDB1 associates with
endogenous DNA methyltransferase activity. SETDB1 interacts with the de novo DNA
methyltransferases DNMT3A and DNMT3B but not with the maintenance methyltransferase …
heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently
identified euchromatic histone methyltransferase SETDB1/ESET may be responsible for
transcriptional repression of certain promoters. Here, we show that SETDB1 associates with
endogenous DNA methyltransferase activity. SETDB1 interacts with the de novo DNA
methyltransferases DNMT3A and DNMT3B but not with the maintenance methyltransferase …