[HTML][HTML] The cone-dominant retina and the inner ear of zebrafish express the ortholog of CLRN1, the causative gene of human Usher syndrome type 3A
JB Phillips, H Västinsalo, J Wegner, A Clément… - Gene Expression …, 2013 - Elsevier
Abstract Clarin-1 (CLRN1) is the causative gene in Usher syndrome type 3A, an autosomal
recessive disorder characterized by progressive vision and hearing loss. CLRN1 encodes
Clarin-1, a glycoprotein with homology to the tetraspanin family of proteins. Previous cell
culture studies suggest that Clarin-1 localizes to the plasma membrane and interacts with
the cytoskeleton. Mouse models demonstrate a role for the protein in mechanosensory hair
bundle integrity, but the function of Clarin-1 in hearing remains unclear. Even less is known …
recessive disorder characterized by progressive vision and hearing loss. CLRN1 encodes
Clarin-1, a glycoprotein with homology to the tetraspanin family of proteins. Previous cell
culture studies suggest that Clarin-1 localizes to the plasma membrane and interacts with
the cytoskeleton. Mouse models demonstrate a role for the protein in mechanosensory hair
bundle integrity, but the function of Clarin-1 in hearing remains unclear. Even less is known …