Fibrinogen is a large, complex, fibrous glycoprotein with three pairs of polypeptide chains
linked together by 29 disulfide bonds. It is 45 nm in length, with globular domains at each
end and in the middle connected by α-helical coiled-coil rods. Both strongly and weakly
bound calcium ions are important for maintenance of fibrinogen's structure and functions.
The fibrinopeptides, which are in the central region, are cleaved by thrombin to convert
soluble fibrinogen to insoluble fibrin polymer, via intermolecular interactions of the “knobs” …